Vignettes

This vignette demonstrates how to use the crmPack package to implement an ordinal continual reassessment method (CRM) for dose-finding clinical trials, which can account for more than one level of toxicity.

Rolling continual reassessment method (CRM) for dose escalation

Jiawen Zhu, Daniel Sabanés Bové

This vignette demonstrates how to implement a rolling continual reassessment method (CRM) for dose escalation using the crmPack package. This design is attractive when reducing the trial duration is a priority, as it…

Several examples how to use crmPack for model-based dose escalation trial design

Ziwei Liao, Daniel Sabanés Bové

This short vignette shall introduce into the usage of the package crmPack. Hopefully it makes it easy for you to set up your own model-based dose escalation design.

Time-to-event continual reassessment method (TITE-CRM) example

Ziwei Liao, Daniel Sabanés Bové

This short vignette demonstrates how to implement a time-to-event continual reassessment method (TITE-CRM) for dose escalation using the crmPack package.

Analyzing an ongoing dose escalation trial

This vignette illustrates how to analyze an ongoing dose escalation trial using crmPack. It continues where the “Trial Definition” vignette ends.

Backfilling cohorts simulation

This vignette illustrates how to simulate a dose escalation trial with backfilling cohorts using crmPack.

Daniel Sabanés Bové

Defining a continual reassessment method trial design in `crmPack`

This vignette describes the starting point for using crmPack - defining a dose escalation trial design using the continual reassessment method (CRM).

Important sanity checks for a dose escalation trial design

This vignette introduces important sanity checks that should be performed on any dose escalation trial design.

Model-based dose escalation designs with `crmPack` (JSS paper)

This is a reprint of the Journal of Statistical Software paper introducing the R package crmPack for model-based dose escalation designs, using slightly adapted syntax of…

Daniel Sabanés Bové, Wai Yin Yeung, Giuseppe Palermo, Thomas Jaki

Feb 13, 2026

Upgrading from `crmPack` version 1.0

Wojciech Wójciak, Oliver Boix

This vignette describes the changes that were introduced to the crmPack package as a result of the package’s refactoring. One row in below tables represents a single-type, consistent change.